# Applications of Polymers in Delivering Biologics
> Ershaid J.M.A.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105023781771
Jurnal / Konferensi: Polymers in Functional Foods and Drugs Chemistry and Essential Applications
Tahun terbit: 2025
DOI: https://doi.org/10.1002/9781394214532.ch9
Citations: 0

## Authors
- Ershaid J.M.A.

## Abstract
The delivery of biologics, such as proteins, DNA, and peptides, faces significant challenges due to their immunogenicity and susceptibility to enzymatic or physical deformation. This chapter explores the key challenges in biologics drug delivery, including their low permeability across biological membranes and their immunogenic nature. Various routes of administration are discussed, each offering distinct advantages and limitations. The central focus of this chapter is the application of polymers in enhancing the delivery of biologics. Both natural and synthetic polymers are evaluated for their applications in delivering biologics. Additionally, a variety of synthetic polymers, including poly(ethylene glycol) (PEG), poly(lacticco-glycolic acid) (PLGA), polylactic acid (PLA), and dendrimers, are explored for their role in protecting biologics from degradation, enhancing permeation, and controlling release kinetics. The chapter concludes by discussing prospects in the field, emphasizing the need for continued innovation in polymer design to overcome the remaining barriers in biologics delivery and improve patient outcomes.

## Keywords
- Nanotechnology
- Polylactic acid
- Natural polymers
- Drug delivery
- Immunogenicity
- Biocompatible material
- Polymer
- Synthetic polymer
- Materials science
- Delivery system
- Biochemical engineering
- Food and drug administration
- Human use
- Synthetic membrane

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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