# BRCA Mutation Status and its Association to Clinicopathological Features in Epithelial Ovarian Cancer
> Muchlis M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105023166485
Jurnal / Konferensi: Journal of Obstetrics Gynecology and Cancer Research
Tahun terbit: 2025
DOI: https://doi.org/10.24200/jogcr.10.12.958
ISSN: 26453991
Kuartil SJR: Q3
Citations: 0

## Authors
- Muchlis M.

## Abstract
Background & Objective: Epithelial Ovarian Cancer (EOC), the most lethal gynecological malignancy, demonstrates distinct biological behaviors in BRCA-mutated cases. This study was conducted with aim of investigating the association between BRCA mutations and clinicopathological features in EOC patients, comparing characteristics between BRCA1 and BRCA2 subtypes.Materials & Methods: This cross-sectional study was conducted at Dr. Wahidin Sudirohusodo Hospital, Makassar (December 2023- December 2024). Forty-seven histologically confirmed EOC patients were included. Clinicopathological data were extracted from medical records, and BRCA status was assessed via genetic testing. Data were analyzed using SPSS software (version 26.0). P<0.05 was considered significant.Results: BRCA mutations were identified in 25.5% (12/47) of patients. The BRCA-positive group compared to BRCA-negative cases exhibited significantly higher CA-125 levels (655.08±184.35 vs 381.54±165.54 U/mL; P<0.001), smaller primary tumors (13.69±5.01 vs 17.75±5.46 cm; P=0.028), and universal bilateral adnexal involvement (100% vs 51.4%; P=0.002). Omental involvement (75% vs 40%; P=0.049) and weight loss (100% vs 71.4%; P=0.046) were more frequent in BRCA-positive patients. No significant differences were found between BRCA1 (n=9) and BRCA2 (n=3) subgroups in tumor size, CA-125, or metastatic patterns.Conclusion: BRCA-mutated EOC demonstrates aggressive features (elevated CA-125, bilateral spread) despite smaller primary tumors, suggesting distinct biological behavior. Early detection of BRCA mutations may aid in determining prognosis and guiding targeted treatment strategies.

## Keywords
- Medicine
- Epithelial ovarian cancer
- Oncology
- Ovarian cancer
- Internal medicine
- Mutation
- BRCA mutation
- Cancer
- Stage (stratigraphy)
- Gynecology
- Cancer research
- Primary tumor
- Proportional hazards model
- Gene
- Genetic testing
- Pathology
- Genetic association
- Germline

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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