# Vaginal Microbial Patterns and Matrix Metalloproteinase-9 Levels in relation to Premature Rupture of Membranes
> Muliati T.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105022422109
Jurnal / Konferensi: Indonesian Journal of Obstetrics and Gynecology
Tahun terbit: 2025
DOI: https://doi.org/10.32771/inajog.v13i3.2741
ISSN: 23386401
Kuartil SJR: Q4
Citations: 0

## Authors
- Muliati T.

## Abstract
Introduction: The premature rupture of membranes (PROM) before the onset of labor, characterized by the painless leakage of fluid from the vagina, can lead to fetal distress and increase the risk of cesarean section. This study analyzed the microbial patterns and matrix metalloproteinase 9 (MMP-9) levels in cases of PROM. Methods: This was an observational study with cross-sectional design. Samples were collected from 60 pregnant women diagnosed with PROM who underwent examination and treatment at St. Khadijah I Hospital in Makassar in November 2023. Statistical analysis was performed using the Independent Samples T-Test for microbial patterns and MMP-9 levels. Results: The MMP-9 level in PROM group was significantly higher (1706,78 ± 386,36) compared to non-PROM group (1328,20 ± 1556,22) with p = 0.006. For microbial pattern, E. coli was the predominant bacteria in PROM group (72,0%) compared to non-PROM group (28,0%) with p = 0.004. Conclusion: The results of this study indicate that high MMP-9 level and predominant E. coli presence in the vaginal swab may increase the risk of PROM.

## Keywords
- Prom
- Medicine
- Premature rupture of membranes
- Observational study
- Obstetrics
- Membrane
- Statistical analysis
- Matrix metalloproteinase
- Gynecology
- Fetal distress
- Matrix (chemical analysis)
- Vagina
- Fetal membrane
- Fetus
- Andrology
- Respiratory distress
- Bacteria
- Internal medicine
- Normal group
- Physiology
- Vaginal discharge

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.