# Fatty acid-heterocyclic hybrids from green algae as novel therapeutic prospects for diabetes management
> Bamahry A.R.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_105018663132
Jurnal / Konferensi: Discover Food
Tahun terbit: 2025
DOI: https://doi.org/10.1007/s44187-025-00636-8
ISSN: 27314286
Kuartil SJR: Q1
Citations: 0

## Authors
- Bamahry A.R.

## Abstract
Abstract Diabetes mellitus is a major global health concern, driven by insulin dysfunction, oxidative stress, and chronic inflammation. Current treatments often have side effects, prompting interest in natural alternatives. Green algae have emerged as a promising source of fatty acid-heterocyclic hybrids—bioactive compounds with improved bioavailability, cell permeability, and multi-target antidiabetic activity. This review highlights their structural features, biosynthesis, extraction, and analysis, along with key mechanisms of action, including enzyme inhibition (α-glucosidase, α-amylase), modulation of insulin signaling (AMPK, PI3K/Akt), antioxidant and anti-inflammatory effects, and beta-cell protection. While preclinical results are promising, further research is needed to standardize activity, enhance bioavailability, and validate efficacy through clinical studies. Fatty acid-heterocyclic hybrids from green algae offer a novel and promising approach to diabetes management.

## Keywords
- Diabetes mellitus
- Biology
- Antioxidant
- Biotechnology
- Algae
- Insulin
- Enzyme
- Biochemistry
- Medicine
- Oxidative phosphorylation
- Fatty liver
- Mechanism (biology)
- Bioinformatics
- Fatty acid
- Metabolic pathway
- Insulin receptor

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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