Analysis of Urine Synaptopodin Levels in Non-Diabetic Adults with Obesity and without Obesity

Abstract

Obesity correlates strongly with insulin resistance and diabetes mellitus and ultimately becomes a major risk factor for kidney disease. Podocytes play a crucial role in maintaining glomerular filtration balance. Synaptopodin is a proline-rich protein closely associated with the actin microfilaments in podocyte foot processes. This study aims to compare urinary synaptopodin levels in non-diabetic obese subjects with non-obese subjects. A cross-sectional study was conducted on males and females without diabetes mellitus who met inclusion and exclusion criteria. Urinary synaptopodin levels were assessed using an ELISA method. The study included 70 participants, comprising 35 males and 35 females. There were 36 obese subjects and 34 non-obese subjects. No significant difference was found in urinary synaptopodin levels between non-obese and obese subjects (0.51±0.43 vs. 0.49±0.37 ng/dL, p=0.672). No correlation was found between urinary synaptopodin levels and body mass index (r = -0.060, p=0.623). Urinary synaptopodin levels did not differ significantly between non-obese and obese subjects.

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