Analysis of Reference Range Values of Lipid Profile and Lipid Ratio in Healthy Young Adult Population in Makassar, Indonesia

Abstract

Background: Lipids are essential for energy, hormones, digestion, and cell structure. A reference range of population-specific lipid profiles is essential due to variations. This study aimed to determine reference ranges for lipid profiles and ratios in healthy young adults in Makassar, Indonesia, and to identify specific differences by gender. Methods: We conducted a cross-sectional study of 120 healthy young adults (61 females, 59 males) aged 20-40 years. Lipid profiles (total cholesterol, LDL, HDL, triglycerides) and ratios (cholesterol/HDL, LDL/HDL, triglycerides/HDL) were measured using spectrophotometry (Cobas C311). Data were analyzed using the Kolmogorov-Smirnov test, and reference ranges were established using 2.5-97.5 percentiles. Results: The overall reference ranges were: cholesterol 133.02-254.75 mg/dL, LDL 73.00-181.82 mg/dL, HDL 23.02-62.97 mg/dL, triglycerides 34.02-319.90 mg/dL, cholesterol/HDL 2.57-8.52, LDL/HDL 1.34-6.13, and triglycerides/HDL 0.60-10.31. Gender-specific ranges showed: women (cholesterol 114.05-252.65 mg/dL, LDL 65.85-175.95 mg/dL, HDL 25.55-75.70 mg/dL, triglycerides 37.30-294.00 mg/dL, cholesterol/HDL 2.55-8.17, LDL/HDL 1.29-5.05, triglycerides/HDL 0. 59-9.64) and men (cholesterol 135.50-255.50 mg/dL, LDL 78.50-196.00 mg/dL, HDL 20.50-61.50 mg/dL, triglycerides 33.50-360.50 mg/dL, cholesterol/HDL 2.54-9.98, LDL/HDL 1.39-6.40, triglycerides/HDL 0.65-17.74). Conclusion: This study established population-specific and gender-specific reference ranges for lipid profiles and ratios in healthy young adults in Makassar, Indonesia, providing valuable clinical data.

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