# Isologous monoclonal antibodies can induce anti‐GBM glomerulonephritis in rats
> Sado Y.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_0026457081
Jurnal / Konferensi: Journal of Pathology
Tahun terbit: 1992
DOI: https://doi.org/10.1002/path.1711680211
ISSN: 00223417
Kuartil SJR: Q1
Citations: 30

## Authors
- Sado Y.

## Abstract
Injection of isologous monoclonal antibodies (SR2, SR3) caused anti-glomerular basement membrane antibody-induced glomerulonephritis (anti-GBM nephritis) in WKY/NCrj rats. The antibodies were obtained from hybridoma cells derived from fusion of the spleen of a nephritic WKY/NCrj rat injected with rat solubilized renal basement membranes with adjuvant, and mouse SP2-myeloma cells. They belonged to the rat IgG2a subclass and bound to rat kidney in a linear pattern along the glomerular and tubular basement membranes. Histological changes in glomeruli were detected at day 1 after the injection; proteinuria with haematuria appeared on day 2; and proteinuria became severe and reached a plateau by day 5. These results demonstrate that anti-GBM nephritis can even be induced by an isologous monoclonal antibody and that the rat IgG2a subclass is at least nephritogenic. The experimental model of anti-GBM nephritis with isologous monoclonal antibodies makes it possible and easier to analyse further the mechanism of anti-GBM nephritis.

## Keywords
- Nephritis
- Monoclonal antibody
- Glomerulonephritis
- Antibody
- Glomerular basement membrane
- Basement membrane
- Subclass
- Kidney
- Monoclonal
- Spleen
- Proteinuria
- Immunology
- Pathology
- Molecular biology
- Biology
- Medicine
- Internal medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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