# Expression of gamma‐glutamyltranspeptidase in cultures of spontaneously and chemically transformed rat liver cells
> Miyazaki M.

URL kanonis: https://discover.unhas.ac.id/publications/pub_scopus_0020507778
Jurnal / Konferensi: International Journal of Cancer
Tahun terbit: 1983
DOI: https://doi.org/10.1002/ijc.2910320318
ISSN: 00207136
Kuartil SJR: Q1
Citations: 17

## Authors
- Miyazaki M.

## Abstract
The expression of gamma-glutamyltranspeptidase (gamma-GTP) and the relationship between this enzyme activity and tumorigenicity were studied in 38 tumorigenic and non-tumorigenic epithelial cell lines derived from livers of normal and aminoazo-dye-fed rats. Nine of 22 non-tumorigenic epithelial cell lines exhibited gamma-GTP-positive cells, whereas 9 of 16 tumorigenic epithelial cell lines did not exhibit gamma-GTP-positive cells. This finding revealed that no correlation existed between the acquisition of gamma-GTP activity and tumorigenicity. None of 10 spontaneously transformed epithelial cell lines, which consisted of 8 tumorigenic and 2 non-tumorigenic cell lines, exhibited gamma-GTP-positive cells. On the other hand, 16 of 28 transformed epithelial cell lines, which were derived from aminoazo-dye-fed rat livers and aminoazo-dye-treated cultures of normal rat liver cells, included gamma-GTP-positive cells in various percentages. As described above, in contrast to in vitro spontaneous transformation of rat liver cells, it is obvious that the carcinogen-induced transformation of rat liver cells in vitro as well as in vivo was frequently accompanied by the acquisition of gamma-GTP-activity. Therefore, it is concluded that the expression of gamma-GTP in liver cells may be mainly associated with exposure to chemical carcinogens.

## Keywords
- GTP'
- Cell culture
- In vitro
- In vivo
- Carcinogen
- Cell
- Chemistry
- Malignant transformation
- Molecular biology
- Biology
- Enzyme
- Biochemistry
- Cancer research
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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