# Prognostic factors and survival rate of childhood acute lymphoblastic leukemia in eastern Indonesia: Kaplan–meier and COX regression approach
> Arsunan A.A.

URL kanonis: https://discover.unhas.ac.id/publications/prognostic-factors-and-survival-rate-of-childhood-acute-lymphoblastic-leukemia-i
Jurnal / Konferensi: Open Access Macedonian Journal of Medical Sciences
Tahun terbit: 2020
DOI: https://doi.org/10.3889/oamjms.2020.5230
ISSN: 18579655
Citations: 1

## Authors
- Arsunan A.A.

## Abstract
BACKGROUND: Acute lymphoblastic leukemia (ALL) is one of the most common childhood hematological malignancies with an incident each year that tends to increase. AIM: This study aims to determine the survival rate of childhood ALL in Dr. Wahidin Sudirohusodo General Hospital and the prognostic factors that influence it. METHODS: A retrospective cohort design was conducted among childhood ALL. The samples were patients ALL diagnosed since January 1, 2014, until 31, 2017, in Dr. Wahidin Sudirohusodo General Hospital. A total of 109 patients were selected by simple random sampling. Data collected through medical records observations. Data were analyzed using Kaplan–Meier and Cox regression analysis. RESULTS: The cumulative survival rate of childhood ALL was 26%. The prognostic factors associated with survival of childhood ALL were nutritional status (p = 0.028), leukocyte counts (p = 0.000), platelet counts (p = 0.000), and comorbidity (p = 0.000). Based on multivariate analysis with Cox regression, the most influencing prognostic factor on survival of ALL patients was comorbidity (p = 0.000, hazard ratio = 3.699 confidence interval 95% 1.945–7.033). Childhood ALL with comorbidities had a risk of death 3699 times higher than childhood ALL without comorbidities. CONCLUSION: Nutritional status, leukocyte counts, platelet counts, and comorbidity were prognostic factors that influence survival of childhood ALL. Comorbidity was the most influencing prognostic factor on survival of childhood ALL.

## Keywords
- Medicine
- Proportional hazards model
- Hazard ratio
- Comorbidity
- Internal medicine
- Survival analysis
- Cohort
- Confidence interval
- Pediatrics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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