# Prevalence of HIV infection and resistance mutations in patients hospitalized for febrile illness in Indonesia
> Merati T.P.

URL kanonis: https://discover.unhas.ac.id/publications/prevalence-of-hiv-infection-and-resistance-mutations-in-patients-hospitalized-fo
Jurnal / Konferensi: American Journal of Tropical Medicine and Hygiene
Tahun terbit: 2021
DOI: https://doi.org/10.4269/ajtmh.20-1595
ISSN: 00029637
Kuartil SJR: Q2
Citations: 12

## Authors
- Merati T.P.

## Abstract
HIV prevalence in Indonesia is increasing, and only 64% of infected individuals know their status. In a prospective cohort of 1,453 hospitalized patients with unexplained fever, 46 (3.2%) had HIV, including 15 (1.1%) patients without a prior HIV diagnosis. Among 31 subjects previously known to have HIV, 21 (68%) had been receiving combination antiretroviral therapy (cART) at the time of enrollment. Of 39 HIV cases with HIV RNA levels ≥ 100 copies/mL, sequencing for genotype analysis and resistance testing was successful in 30 (77%) subjects. The most common HIV subtypes were AE (90%) and B (10%). Five (16.7%) subjects had resistance mutations to nucleoside and non-nucleoside reverse transcriptase inhibitors, and all of them were on cART. No evidence of transmitted drug resistance was found in newly diagnosed individuals. Hospital-based screening may be an efficient method to expand HIV testing and identify a significant number of new cases. Access to care, close monitoring, expansion of anti-retroviral options, and ensuring availability of CD4 determinations, viral load testing, and genotyping are crucial to control of the epidemic in Indonesia.

## Keywords
- Cart
- Medicine
- Genotyping
- Drug resistance
- Viral load
- Cohort
- Genotype
- HIV drug resistance
- Human immunodeficiency virus (HIV)
- Virology
- Internal medicine
- Cohort study
- Prospective cohort study
- Reverse transcriptase
- Immunology
- Antiretroviral therapy
- Biology
- Polymerase chain reaction
- Biochemistry
- Gene
- Microbiology
- Engineering
- Mechanical engineering

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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