Potential Use of Breadfruit (Artocarpus altilis) Leaf Extract to Recover Hepatic and Renal Damage in Alloxan-Induced Diabetic Rats

Abstract

The antihyperglycemic effect of breadfruit leaf (Artocarpus altilis)extract has been demonstrated in a preclinical study using an alloxaninduceddiabetic model. This study aimed to examine whetherbreadfruit leaf extract also ameliorated liver and kidney injury inalloxan-induced diabetic rats. Male Wistar rats (n=35) were usedin the study. All other animals except control group (group I, n=5)were injected with alloxan (155 mg/kg body weight). After 3 days,the hyperglycemic rats with blood glucose >200 mg/dl were dividedinto 4 treatment groups: placebo (alloxan group), Breadfruit Leaf(BL) extract 100 mg/kg, BL extract 200 mg/kg, and BL extract 400mg/kg. Treatments were administered daily for 14 days, and bloodsamples were drawn at baseline, after alloxan injection, and followingtreatments to obtain serum glutamic pyruvic transaminase (SGPT)and creatinine levels. Alloxan was found to cause a significantincrease in rat blood glucose, SGPT, and creatinine levels three dayspost alloxan injection (P

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