# Picrajavanicins A-G, Quassinoids from Picrasma javanica Collected in Myanmar
> Win N.N.

URL kanonis: https://discover.unhas.ac.id/publications/picrajavanicins-a-g-quassinoids-from-picrasma-javanica-collected-in-myanmar
Jurnal / Konferensi: Journal of Natural Products
Tahun terbit: 2015
DOI: https://doi.org/10.1021/acs.jnatprod.5b00824
ISSN: 01633864
Kuartil SJR: Q1
Citations: 23

## Authors
- Win N.N.

## Abstract
Seven new tetracyclic quassinoids, picrajavanicins A-G (1-7), along with three known analogues, were isolated from a CHCl3-soluble extract of the bark of Picrasma javanica collected in Myanmar. The structures of these compounds were elucidated using spectroscopic techniques, including 1D and 2D NMR. The absolute configuration at C-2 of 2 was determined to be S by the modified Mosher method. All the isolates were tested for their antiproliferative activities against a small panel of five human cancer cell lines. However, none of the isolated compounds exhibited inhibitory activity against any of the cancer cells used (IC50 values >10 μM).

## Keywords
- Bark (sound)
- Simaroubaceae
- Stereochemistry
- Traditional medicine
- Chemistry
- Pharmacognosy
- IC50
- Cancer cell lines
- Absolute configuration
- Biology
- Biological activity
- In vitro
- Cancer cell
- Biochemistry
- Cancer
- Medicine
- Ecology
- Genetics

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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