# Phenethyl p-coumarate and N-phenethyl-p-coumaramide: Synthesis, Characterization, Docking Studies and Anticancer Activity through P388 Cell
> Firdaus

URL kanonis: https://discover.unhas.ac.id/publications/phenethyl-p-coumarate-and-n-phenethyl-p-coumaramide-synthesis-characterization-d
Jurnal / Konferensi: Sains Malaysiana
Tahun terbit: 2022
DOI: https://doi.org/10.17576/jsm-2022-5104-11
ISSN: 01266039
Kuartil SJR: Q2
Citations: 3

## Authors
- Firdaus

## Abstract
Most p-coumaric acid derivatives and molecules containing phenethyl moiety have a potential in anticancer activity. Thus, combining a p-coumaroyl group and a phenethyl moiety in one compound will increase anticancer activity. The principal objective of this research was to incorporate p-coumaroyl and phenethyl moieties to form an ester, phenethyl p-coumarate (5), and an amide, N-phenethyl-p-coumaramide (6), then tested their anticancer activity using P388 leukemia murine cells. The characterization by FTIR method, compound 5 gave a strong absorption band of alkyl C-O bond that appears at 1165,00 cm-1, and compound 6 gave a sharp and medium absorption band of N-H bond that appears at 3396.64 cm-1. Docking studies of both compounds showed a hydrogen bond with Ile839 residue, and an additional hydrogen bond appeared between compound 6 and Ser991 residue. Based on their activity against P388 leukemia murine cells, these compounds are more active than their analog compounds of N-feruloylpiperidine and N-feruloylmorpholine, which have been synthesized previously. Compounds 5 and 6 have a high potential to be used as anticancer drugs.

## Keywords
- Chemistry
- Moiety
- Docking (animal)
- Stereochemistry
- Amide
- Hydrogen bond
- Residue (chemistry)
- Benzamide
- Carboxamide
- Molecule
- Biochemistry
- Organic chemistry
- Nursing
- Medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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