# Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes
> Goodman C.D.

URL kanonis: https://discover.unhas.ac.id/publications/parasites-resistant-to-the-antimalarial-atovaquone-fail-to-transmit-by-mosquitoe
Jurnal / Konferensi: Science
Tahun terbit: 2016
DOI: https://doi.org/10.1126/science.aad9279
ISSN: 00368075
Kuartil SJR: Q1
Citations: 124

## Authors
- Goodman C.D.

## Abstract
Drug resistance compromises control of malaria. Here, we show that resistance to a commonly used antimalarial medication, atovaquone, is apparently unable to spread. Atovaquone pressure selects parasites with mutations in cytochrome b, a respiratory protein with low but essential activity in the mammalian blood phase of the parasite life cycle. Resistance mutations rescue parasites from the drug but later prove lethal in the mosquito phase, where parasites require full respiration. Unable to respire efficiently, resistant parasites fail to complete mosquito development, arresting their life cycle. Because cytochrome b is encoded by the maternally inherited parasite mitochondrion, even outcrossing with wild-type strains cannot facilitate spread of resistance. Lack of transmission suggests that resistance will be unable to spread in the field, greatly enhancing the utility of atovaquone in malaria control.

## Keywords
- Atovaquone
- Virology
- Malaria
- Biology
- Plasmodium falciparum
- Immunology

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.