# Oral Doxycycline on the Level of Matrix Metalloproteinase 9 in Rat Models Experiencing Traumatic Brain Injury
> Daud K.R.

URL kanonis: https://discover.unhas.ac.id/publications/oral-doxycycline-on-the-level-of-matrix-metalloproteinase-9-in-rat-models-experi
Jurnal / Konferensi: Iium Medical Journal Malaysia
Tahun terbit: 2021
DOI: https://doi.org/10.31436/IMJM.V20I1.1773
ISSN: 27352285
Kuartil SJR: Q4
Citations: 4

## Authors
- Daud K.R.

## Abstract
INTRODUCTION: Cerebral edema in traumatic brain injury (TBI) results from hyperpermeability of the bloodbrain barrier (BBB). One of the causes in BBB permeability disorders is the activation of matrix metalloproteinase 9 (MMP-9) which can be inhibited by the administration of doxycycline. Knowing the role of oral doxycycline administration as an inhibitor of MMP-9 activation on the level of MMP-9 in cerebral edema in traumatic brain injury. MATERIALS AND METHODS: This study was an experimental study in Wistar rats with a post-test control design consisting of one control group, one group with provoked brain injury, and one group with provoked brain injury followed by oral doxycycline administration. RESULT: There were significant differences in the level of MMP -9 between the control group, the provoked brain injury group and the provoked brain injury group followed by oral doxycycline administration with p-value = 0.01 (p<0.05). CONCLUSION: Oral doxycycline administration can inhibit the increase of MMP-9 levels in cerebral edema in traumatic brain injury in Wistar rats.

## Keywords
- Doxycycline
- Medicine
- Traumatic brain injury
- Matrix metalloproteinase
- Edema
- Cerebral edema
- Oral administration
- Brain edema
- Matrix metalloproteinase 9
- Anesthesia
- Evans Blue
- Pharmacology
- Internal medicine
- Antibiotics
- Psychiatry
- Biology
- Microbiology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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