# Nitric oxide‐releasing bacterial cellulose/chitosan crosslinked hydrogels for the treatment of polymicrobial wound infections
> Hasan N.

URL kanonis: https://discover.unhas.ac.id/publications/nitric-oxidereleasing-bacterial-cellulosechitosan-crosslinked-hydrogels-for-the
Jurnal / Konferensi: Pharmaceutics
Tahun terbit: 2022
DOI: https://doi.org/10.3390/pharmaceutics14010022
ISSN: 19994923
Kuartil SJR: Q1
Citations: 32

## Authors
- Hasan N.

## Abstract
Polymicrobial wound infections are a major cause of infectious disease-related morbidity and mortality worldwide. In this study, we prepared a nitric oxide (NO)-releasing oxidized bacterial cellulose/chitosan (BC<sub>TO</sub>/CHI) crosslinked hydrogel to effectively treat polymicrobial wound infections. Linear polyethyleneimine diazeniumdiolate (PEI/NO) was used as the NO donor. The aldehyde group of BC<sub>TO</sub> and the amine of CHI were used as crosslinked hydrogel-based materials; their high NO loading capacity and antibacterial activity on the treatment of polymicrobial-infected wounds were investigated. The blank and NO-loaded crosslinked hydrogels, namely BC<sub>TO</sub>-CHI and BC<sub>TO</sub>-CHI-PEI/NO, were characterized according to their morphologies, chemical properties, and drug loading. BC<sub>TO</sub>-CHI-PEI/NO exhibited sustained drug release over four days. The high NO loading of BC<sub>TO</sub>-CHI-PEI/NO enhanced the bactericidal efficacy against multiple bacteria compared with BC<sub>TO</sub>-CHI. Furthermore, compared with blank hydrogels, BC<sub>TO</sub>-CHI-PEI/NO has a favorable rheological property due to the addition of a polymer-based NO donor. Moreover, BC<sub>TO</sub>-CHI-PEI/NO significantly accelerated wound healing and re-epithelialization in a mouse model of polymicrobial-infected wounds. We also found that both crosslinked hydrogels were nontoxic to healthy mammalian fibroblast cells. Therefore, our data suggest that the BC<sub>TO</sub>-CHI-PEI/NO developed in this study improves the efficacy of NO in the treatment of polymicrobial wound infections.

## Keywords
- Self-healing hydrogels
- Chitosan
- Bacterial cellulose
- Wound healing
- Nitric oxide
- Antibiotics
- Cellulose
- Medicine
- Microbiology
- Materials science
- Chemistry
- Immunology
- Polymer chemistry
- Biology
- Biochemistry
- Internal medicine

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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