# Nanosuspension-based dissolving microneedle arrays for intradermal delivery of curcumin > Abdelghany S. URL kanonis: https://discover.unhas.ac.id/publications/nanosuspension-based-dissolving-microneedle-arrays-for-intradermal-delivery-of-c Jurnal / Konferensi: Pharmaceutics Tahun terbit: 2019 DOI: https://doi.org/10.3390/pharmaceutics11070308 ISSN: 19994923 Kuartil SJR: Q1 Citations: 130 ## Authors - Abdelghany S. ## Abstract The objective of this study was to evaluate the intradermal delivery of curcumin utilising poly(vinylalcohol) (PVA)-based microneedles loaded with curcumin nanosuspension (CU-NS). Nanoprecipitation was used to formulate the CU-NS which was then incorporated into PVA microneedles arrays consisting of 11 × 11 microneedles of conical shape, measuring 900 µm in height and with 300 µm base diameter. The nanosuspension particle size was 520 ± 40 nm, with a polydispersity of 0.27 ± 0.02 using sodium lauryl sulfate (SLS) as a stabiliser. In vitro dissolution studies in 10% w/v Tween 80 showed that the CU-NS dissolved significantly faster than unmodified curcumin powder, with 34% released from the CU-NS, compared to 16% from the curcumin powder after 48 h. The CU-NS-loaded microneedles (CU-MN) were able to withstand a compression force of 32 N for 30 s. Moreover, these microneedles were able to penetrate excised neonatal porcine skin to a depth of 500 µm, dissolved completely in the skin within 60 min. After CU-MN dissolution, the drug diffused from the application site and migrated through the skin layers down to 2300 µm, significantly more than observed with topical application of CU-NS. This suggest that the fabricated microneedles with the incorporated CU-NS could enhance the intradermal delivery of curcumin. ## Keywords - Curcumin - Dissolution - Dispersity - Materials science - Stabiliser - Nuclear chemistry - Nanotechnology - Drug delivery - Biomedical engineering - Chemistry - Polymer chemistry - Organic chemistry - Biochemistry - Medicine --- Sumber: Discover Unhas — RIMS Universitas Hasanuddin. Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.