Molecular Patho-mechanisms of cervical cancer (MMP1)

Abstract

Cervical cancer mostly caused by Human Papilloma Virus. Staging and therapy have been extensively studied, and highly correlated with the cellular development of oncogenesis. Mutation was caused by E6 and E7 oncoprotein, also inactivation of 2 tumor suppressor factors (pRB and p53). P53 also regulated MMP1, which dysregulation of MMP transcription would promote tumor metastasis, because of its role in extracellular matrix degradation in tumor invasion. Clinical staging of Cervical Cancer was based on Federation International of Gynaecology and Obstetrics (FIGO) classification from 2018. Management was divided into Surgery, Radiotherapy, and Chemotherapy. HIGHLIGHTS Metalloproteinase from a matrix, known as Matrixin or MMP (Matrix Metallo Proteinase), was part of sub-group of zinc-endoproteinase, produced by soft tissue. This enzyme then involved in an important cascade that resulted in soft tissue degradation, either physiologically or pathologically. Matrix metalloproteinases (MMPs) have two opposite functions, which are promoting and inhibition of cancer. Physiologically, MMP expression was very low or even zero in all of human's tissues. It only increased in reactive or reparative condition.

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