# Molecular mechanisms of lidocaine
> Karnina R.

URL kanonis: https://discover.unhas.ac.id/publications/molecular-mechanisms-of-lidocaine
Jurnal / Konferensi: Annals of Medicine and Surgery
Tahun terbit: 2021
DOI: https://doi.org/10.1016/j.amsu.2021.102733
ISSN: 20490801
Citations: 85

## Authors
- Karnina R.

## Abstract
Lidocaine is an amide-class local anesthetic used clinically to inhibit pain sensations. Systemic administration of lidocaine has antinociceptive, antiarrhythmic, anti-inflammatory, and antithrombotic effects. Lidocaine exerts these effects under both acute and chronic pain conditions and acute respiratory distress syndrome through mechanisms that can be independent of its primary mechanism of action, sodium channel inhibition. Here we review the pathophysiological underpinnings of lidocaine's role as an anti-nociceptive, anti-inflammatory mediated by toll-like receptor (TLR) and nuclear factor kappa-β (NF-kβ) signalling pathways and downstream cytokine effectors high mobility group box 1 (HMGB1) and tumour necrosis factor-α (TNF-α).

## Keywords
- Medicine
- Lidocaine
- Local anesthetic
- Pharmacology
- Anesthesia
- Nociception
- Pathophysiology
- Mechanism of action
- Acute respiratory distress
- Receptor
- Internal medicine
- Lung
- Chemistry
- In vitro
- Biochemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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