# Kleinhospitine e and Cycloartane Triterpenoids from Kleinhovia hospita
> Rahim A.

URL kanonis: https://discover.unhas.ac.id/publications/kleinhospitine-e-and-cycloartane-triterpenoids-from-kleinhovia-hospita
Jurnal / Konferensi: Journal of Natural Products
Tahun terbit: 2018
DOI: https://doi.org/10.1021/acs.jnatprod.8b00211
ISSN: 01633864
Kuartil SJR: Q1
Citations: 23

## Authors
- Rahim A.

## Abstract
A novel cycloartane triterpenoid alkaloid, kleinhospitine E (1), six new cycloartane triterpenoids (2-7), three known cycloartane triterpenoids (8-10), and taraxerone (11) were isolated from a methanol extract of Kleinhovia hospita. Their structures were elucidated by 1D- and 2D-NMR spectroscopy as well as HRMS analysis. The absolute configurations of all isolated compounds were determined from their ECD spectra by comparison with theoretical values. Kleinhospitine E (1) is the first cycloartane alkaloid possessing an unusual γ-lactam with an oxopropylidene side chain. Compounds 2, 3, and 6 were assigned as cycloartane triterpenoids with a 9α,10α-cyclopropyl ring, which is found rarely among naturally occurring compounds, while 4 and 5 were established as isomers of compound 3 containing a 21,23-diacetal side chain. Biological evaluation revealed that compounds 4 and 9 exhibited more potent antiproliferative activities against a multidrug-resistant tumor cell line compared with its parent chemosensitive cell line. Furthermore, compound 6 exhibited submicromolar anti-HIV activity.

## Keywords
- Stereochemistry
- Chemistry
- Triterpenoid
- Alkaloid
- Two-dimensional nuclear magnetic resonance spectroscopy
- Triterpene
- Medicine
- Pathology
- Alternative medicine

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.