Integrating blood biochemistry and plasma metabolomics to define age-related metabolic biomarkers in Alope village chickens

Abstract

Age was the primary determinant of metabolic organization in Alope village chickens from 8 to 16 weeks. The integration of blood biochemistry and plasma metabolomics revealed coordinated physiological transitions from early growth toward enhanced energy handling and metabolic stabilization. The identified candidate metabolites provide an exploratory framework for defining physiological age and support the potential application of age-informed metabolic indicators for precision nutrition and health monitoring in indigenous village chicken production systems.

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