# Inflammation-mediated phenoconversion: A potential threat to covid-19 pharmacotherapy
> Akbar Bahar M.

URL kanonis: https://discover.unhas.ac.id/publications/inflammation-mediated-phenoconversion-a-potential-threat-to-covid-19-pharmacothe
Jurnal / Konferensi: Hayati Journal of Biosciences
Tahun terbit: 2021
DOI: https://doi.org/10.4308/hjb.28.1.54
ISSN: 19783019
Kuartil SJR: Q3
Citations: 1

## Authors
- Akbar Bahar M.

## Abstract
One of the important hallmarks of coronavirus disease 2019 (COVID-19) is the existence of severe inflammatory responses. Many reports indicated that inflammatory mediators might suppress the biological functions of some drug metabolizing enzymes and transporters, and therefore result in a transient mismatch between their genotype and phenotype expressions, a phenomenon which is called phenoconversion. The incidence might be clinically relevant to the COVID-19 patients with comorbidities. The patients are treated with multiple drugs that are prone to be altered pharmacokinetically by inflammation-mediated phenoconversion, leading to the modification of their effectiveness and safety. In this review, we discuss the regulation of inflammatory responses during COVID-19 infection and the evidence as well as potential mechanisms of inflammation-mediated phenoconversion. We also provide possible clinical implications of such phenoconversion events as a potential threat in the management of COVID-19 patients.

## Keywords
- Inflammation
- Medicine
- Coronavirus disease 2019 (COVID-19)
- Pharmacotherapy
- Disease
- Pharmacogenetics
- Immunology
- Bioinformatics
- Genotype
- Biology
- Internal medicine
- Infectious disease (medical specialty)
- Gene
- Biochemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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