# Increased Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) value is not related to glomerular filtration rate in healthy non-diabetic young adults
> Hidayat M.R.

URL kanonis: https://discover.unhas.ac.id/publications/increased-homeostatic-model-assessment-of-insulin-resistance-homa-ir-value-is-no
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2024
DOI: https://doi.org/10.23736/S0393-3660.23.05164-1
ISSN: 03933660
Kuartil SJR: Q4
Citations: 2

## Authors
- Hidayat M.R.

## Abstract
BACKGROUND: Insulin resistance occurs several decades before the onset of diabetes mellitus and other cardiovascular diseases. This condition is often associated with overweight and type-2 diabetes, and is a major risk factor for various chronic diseases such as cardiovascular disease, metabolic syndrome, and kidney failure. Insulin resistance appears at an extremely early stage of chronic kidney disease (CKD) and is clearly visible when GFR is within the normal range. To this end, we aim to assess the association between HOMA-IR and GFR in non-diabetic young adults.METHODS: This cross-sectional study involved 98 non-diabetic young adult subjects. Insulin resistance was estimated using HOMA-IR while glomerular filtration rate was measured by the CKD-EPI equation. Furthermore, statistical analysis was performed using ANOVA and Chi Square tests, with the results being considered significant if the P value <0.05. Another analysis of the confounding variables was made by the Spearman correlation coefficient.RESULTS: Of 98 subjects, 33 people (33.7%) had high HOMA-IR value (tertile 3), with a HOMA-IR cut-off of more than 2.03. Among these subjects, 3 people (9.1%) had GFR<90. There was no association between HOMA-IR and GFR in the GFR groups (GFR <90 and GFR≥90). However, from the analysis of the confounding variables, Body Mass Index (BMI) was found to have a significantly negative correlation with GFR (P=0.014).CONCLUSIONS: No significant association was found between HOMA-IR value and GFR in non-diabetic young adult subjects.

## Keywords
- Insulin resistance
- Homeostatic model assessment
- Renal function
- Homeostasis
- Internal medicine
- Endocrinology
- Medicine
- Diabetes mellitus

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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