In vitro antibacterial and anticancer activity of Zn(II)Valinedithiocarbamate complexes

Abstract

Abstract A new complex of Zn(II) that contain amino acid valine and dithiocarbamate ligands were synthesized and characterized by using Ultraviolet Visible (UV-Vis), Infra Red (IR) spectroscopy, X-Ray Fluoroscence (XRF), X-Ray Diffraction (XRD), melting point and molar conductance. The complex was prepared by “in situ method” and showed that complexes are successfully synthesis. The invitro cytotoxic complexes compound was examined againts MCF-7 (breast cancer) using cis-Pt drug as a control positive and the complexes exhibit very strong invitro cytotoxic againts MCF-7 based on IC 50 data is 639,35 µg/mL which indicates that the complex can induce the morphological MCF-7 cancer cells changes towards apoptosis. Complexes compound were evaluated as their antibacterial agents activity against of mycobacterium tuberculosa H37RV using LJ method and results show these complexes are potential as anti-tuberculosis agents. Therefore this complexes compounds can be use to new drugs compound in the treatment againts of MCF-7 and tuberculosis.

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