# Improved transdermal delivery of valsartan using combinatorial approach of polymeric transdermal hydrogels and solid microneedles: an ex vivo proof of concept investigation
> Enggi C.K.

URL kanonis: https://discover.unhas.ac.id/publications/improved-transdermal-delivery-of-valsartan-using-combinatorial-approach-of-polym
Jurnal / Konferensi: Journal of Biomaterials Science Polymer Edition
Tahun terbit: 2023
DOI: https://doi.org/10.1080/09205063.2022.2121590
ISSN: 09205063
Kuartil SJR: Q2
Citations: 7

## Authors
- Enggi C.K.

## Abstract
Valsartan (VAL) is used as a first-line agent to treat hypertension. However, VAL exhibits poor absorption and low bioavailability when administrated orally. To overcome these issues, VAL transdermal gel was developed in this study, where Carbopol was used as the gel matrices. Additionally, solid microneedles (Dermaroller<sup>®</sup>) with various needle lengths were combined with transdermal gel to improve its permeation across the stratum corneum as a skin barrier. Developed formulations were further evaluated for various parameters, including pH, viscosity, spreadability, extrudability, gel strength, drug content, <i>ex vivo</i> permeation, <i>in vitro</i> release, occlusivity, and hemolysis. The results showed that all formulations exhibited desired physical characteristics without any potential to cause toxicity. Moreover, this approach showed that using microneedles could significantly enhance the permeation of VAL up to 3 folds compared to untreated skin. The use of microneedles 1.5 mm was found to be the optimum combination to improve VA permeation without affecting skin integrity. As much as 1.69 ± 0.004 mg of VAL permeated after 8 h. Finally, it could be concluded that this work had successfully developed a new approach for VALS drug delivery and could potentially show a significant impact on the treatment of hypertension. Further <i>in vivo</i> work should be considered.

## Keywords
- Transdermal
- Permeation
- Ex vivo
- Stratum corneum
- Bioavailability
- Materials science
- Valsartan
- Biomedical engineering
- In vivo
- Self-healing hydrogels
- Poloxamer
- Chromatography
- Drug delivery
- Pharmacology
- Polymer
- Chemistry
- Nanotechnology
- Composite material
- Medicine
- Polymer chemistry
- Blood pressure
- Biology
- Radiology
- Biochemistry
- Biotechnology
- Membrane
- Copolymer
- Pathology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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