Immunomodulatory effect of orally red fruit (Pandanus conoideus) extract on the expression of CC chemokine receptor 5 mRNA in HIV patients with antiretroviral therapy

Abstract

Background and Objective: The C-C chemokine receptor 5 (CCR5) is a coreceptor of human immunodeficiency virus (HIV) and is related to immune cells. Therefore, it was investigated immunostimulant effect of red fruit (Pandanus conoideus) oil extract on the level of CCR5 mRNA in HIV infected patients with taking antiretroviral therapy. Materials and Methods: Seventy of HIV infected patients (age of 17-45 years) were into the antiretroviral (ARV) control (n = 35) and the antiretroviral+red fruit capsule (ARV+RFC)-treated (n = 35) groups. In ARV+RFC group, they were given oral RFC (1 g daily for two months). Monitoring evaluations of the laboratory were performed at baseline (0 months) and two months during the study. The quantification of CCR5 messenger ribonucleic acid (mRNA) in human blood immune cells was determined using real-time reverse transcriptase polymerase chain reaction (RT-PCR) assay. Results: In this study, it was found that ARV+RFC exhibited a significantly increased level of CCR5 mRNA of HIV-infected patients compared with ARV alone (p<0.001). Conclusion: From this, it was concluded that the red fruit oil extract may have an excellent immunostimulant effect and has potential as an adjuvant in the management of HIV-infected patients.

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