# Hurdles to breakthrough in CAR T cell therapy of solid tumors
> Marofi F.

URL kanonis: https://discover.unhas.ac.id/publications/hurdles-to-breakthrough-in-car-t-cell-therapy-of-solid-tumors
Jurnal / Konferensi: Stem Cell Research and Therapy
Tahun terbit: 2022
DOI: https://doi.org/10.1186/s13287-022-02819-x
ISSN: 17576512
Kuartil SJR: Q1
Citations: 45

## Authors
- Marofi F.

## Abstract
Abstract Autologous T cells genetically engineered to express chimeric antigen receptor (CAR) have shown promising outcomes and emerged as a new curative option for hematological malignancy, especially malignant neoplasm of B cells. Notably, when T cells are transduced with CAR constructs, composed of the antigen recognition domain of monoclonal antibodies, they retain their cytotoxic properties in a major histocompatibility complex (MHC)-independent manner. Despite its beneficial effect, the current CAR T cell therapy approach faces myriad challenges in solid tumors, including immunosuppressive tumor microenvironment (TME), tumor antigen heterogeneity, stromal impediment, and tumor accessibility, as well as tribulations such as on-target/off-tumor toxicity and cytokine release syndrome (CRS). Herein, we highlight the complications that hamper the effectiveness of CAR T cells in solid tumors and the strategies that have been recommended to overcome these hurdles and improve infused T cell performance.

## Keywords
- Chimeric antigen receptor
- Cancer research
- Cytotoxic T cell
- Major histocompatibility complex
- Stromal cell
- Antigen
- Tumor microenvironment
- Monoclonal antibody
- Immunology
- T cell
- Immunotherapy
- Malignancy
- Medicine
- Biology
- Antibody
- Tumor cells
- Immune system
- Pathology
- Biochemistry
- In vitro

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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