# Herbal medicine goshajinkigan prevents paclitaxel-induced mechanical allodynia without impairing antitumor activity of paclitaxel
> Bahar M.

URL kanonis: https://discover.unhas.ac.id/publications/herbal-medicine-goshajinkigan-prevents-paclitaxel-induced-mechanical-allodynia-w
Jurnal / Konferensi: Evidence Based Complementary and Alternative Medicine
Tahun terbit: 2013
DOI: https://doi.org/10.1155/2013/849754
ISSN: 1741427X
Citations: 27

## Authors
- Bahar M.

## Abstract
Chemotherapy-induced peripheral neuropathy is a major dose-limiting side effect of commonly used chemotherapeutic agents. However, there are no effective strategies to treat the neuropathy. We examined whether Goshajinkigan, a herbal medicine, would prevent paclitaxel-induced allodynia without affecting the anticancer action in mice. Murine breast cancer 4T1 cells were inoculated into the mammary fat pad. Paclitaxel (10 and 20 mg/kg, intraperitoneal, alternate day from day 7 postinoculation) inhibited the tumor growth, and Goshajinkigan (1 g/kg, oral, daily from day 2 postinoculation) did not affect the antitumor action of paclitaxel. Mechanical allodynia developed in the inoculated region due to tumor growth and in the hind paw due to paclitaxel-induced neuropathy. Paclitaxel-induced allodynia was markedly prevented by Goshajinkigan, although tumor-associated allodynia was not inhibited by Goshajinkigan. These results suggest that Goshajinkigan prevents paclitaxel-induced peripheral neuropathy without interfering with the anti-cancer action of paclitaxel.

## Keywords
- Paclitaxel
- Peripheral neuropathy
- Medicine
- Allodynia
- Pharmacology
- Chemotherapy
- Cancer
- Hyperalgesia
- Internal medicine
- Endocrinology
- Receptor
- Nociception
- Diabetes mellitus

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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