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Hemoglobin characteristics of Rattus norvegicus by oral Moringa oleifera and folic acid
Sulfika S.
Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Q4Abstract
BACKGROUND: Hemoglobin is an iron-rich protein in red blood cells that binds oxygen in the blood and carries it throughout the body if the number of erythrocytes or low hemoglobin levels can cause anemia. Currently, there have been many studies using female mice. However, there is still little information about hemoglobin levels in experimental animals, especially in female mice induced by toxic doses of acetaminophen and given Moringa oleifera and folic acid. So, this study aims to analyze the effect of Moringa oleifera and Folic Acid on Hemoglobin levels in Rattus norvegicus rats.METHODS: This experimental study uses a post-test-only control group design in white rats (Rattus norvegicus). Rats were given a toxic dose of acetaminophen (1000 mg/kg BW) and then given Moringa oleifera and folic acid as hepatoprotectors. Blood samples were taken from the retro-orbital sinus for analysis of hemoglobin levels. Data were analyzed using the Kruskal-Wallis test because the data were not normally distributed.RESULTS: The results of the analysis of the average hemoglobin levels stated that there was no significant difference.CONCLUSIONS: Moringa oleifera and folic acid had no significant effect on hemoglobin levels in Rattus norvegicus rats induced by toxic doses of acetaminophen.