# Green synthesis of MnFe2O4nanoparticles using Elaeis guineensis Jacq. leaves and empty fruit bunches extract and its radiolabeling with 99mTc as a potential agent for dual-modality imaging SPECT/MRI
> Putra A.R.

URL kanonis: https://discover.unhas.ac.id/publications/green-synthesis-of-mnfe2o4nanoparticles-using-elaeis-guineensis-jacq-leaves-and
Jurnal / Konferensi: Radiochimica Acta
Tahun terbit: 2025
DOI: https://doi.org/10.1515/ract-2024-0368
ISSN: 00338230
Kuartil SJR: Q4
Citations: 1

## Authors
- Putra A.R.

## Abstract
Abstract This study aimed to develop a novel material for dual-modality SPECT/MRI. MnFe 2 O 4 nanoparticles (NPs) were synthesized via a green method using Elaeis guineensis Jacq. extracts (leaf extract – ELE and empty fruit bunches extract – EFBE) at an optimal calcination temperature of 400 °C. Characterization by FTIR, XRD, SEM, TEM, SAED, TGA, and VSM revealed NPs with an average size of 28.6 ± 9.6 nm and a magnetization value of 38.2 emu/g. The optimal conjugation with human serum albumin (HSA) was achieved at a 1:1 ratio, yielding approximately 0.388 ± 0.049 mg per mg of HSA. Radiolabeling of [ 99m Tc]Tc-HSA-MnFe 2 O 4 NPs was characterized using HPLC and TLC to assess impurities, demonstrating radiochemical purity exceeding 99 % across various media, including PBS, saline, water and human serum. Further studies are necessary to evaluate the biological profiles using in vitro and in vivo assays.

## Keywords
- Elaeis guineensis
- Chemistry
- Nanoparticle
- Horticulture
- Food science
- Palm oil
- Nanotechnology
- Biology
- Materials science

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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