# Gastroulcerogenic Evaluation of Ibuprofen Ester Conjugates
> Rifai Y.

URL kanonis: https://discover.unhas.ac.id/publications/gastroulcerogenic-evaluation-of-ibuprofen-ester-conjugates
Jurnal / Konferensi: Journal of Physics Conference Series
Tahun terbit: 2019
DOI: https://doi.org/10.1088/1742-6596/1341/7/072007
ISSN: 17426588
Citations: 1

## Authors
- Rifai Y.

## Abstract
The aim of this study is to search for any potential gastric ulcerogenic properties of the ester form of ibuprofen in comparison with Ibuprofen in order to establish the gastrointestinal safety profile. Ibuprofen ester derivates were synthesized and were tested for their gastroulcerogenic side effects. The esterification of ibuprofen suppressed its gastric ulceration which is associated with its side effect as an antiinflammation. Research results showed that the rat group given Ibuprofen ester conjugate compound had fewer ulcers, smaller ulcer diameters, and less severe ulcer onditions. Histological examination showed that rat in the group given Ibuprofen ester conjugates had lesser number of hemorrhage and congestion compared to the group given ibuprofen. In conclusion, the treatment of Ibuprofen ester conjugates has a lower risk of ulcerogenic effects than the treatment of ibuprofen.

## Keywords
- Ibuprofen
- Conjugate
- Medicine
- Chemistry
- Significant difference
- Pharmacology
- Internal medicine
- Mathematics
- Mathematical analysis

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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