# Fibrous dysplasia of the maxilla: radiographic and histopathologic correlation in a challenging diagnosis – a case report with literature review
> Alfina R.

URL kanonis: https://discover.unhas.ac.id/publications/fibrous-dysplasia-of-the-maxilla-radiographic-and-histopathologic-correlation-in
Jurnal / Konferensi: Romanian Journal of Stomatology
Tahun terbit: 2025
DOI: https://doi.org/10.37897/RJS.2025.3.5
ISSN: 18430805
Kuartil SJR: Q3
Citations: 0

## Authors
- Alfina R.

## Abstract
Background. Fibrous dysplasia (FD) is a benign and uncommon bone disorder that arises from a mutation in the GNAS gene, replacing normal bone with fibrous tissue and abnormal (woven) bone. Case report. 50-year-old woman presented with a one-year history of asymptomatic right maxillary swelling that posed a risk of future masticatory dysfunction. CBCT revealed an aggressive unilocular lesion with a granular “ground-glass” pattern expanding into the maxillary sinus – a pattern seen in <10% of maxillary FD cases. Histopathology confirmed FD, showing fibrocellular stroma with immature trabeculae lacking osteoblastic rimming. Due to extensive involvement, a right hemimaxillectomy was performed with no perioperative complications. The case underscores FD’s diagnostic challenges, mimicking other fibro-osseous lesions radiographically, necessitating histopathologic correlation. The patient was discharged in stable condition but was unfortunately lost to follow-up, limiting assessment of postoperative recovery and recurrence risk. Conclusions. FD is typically benign, but rare malignant transformation warrants surveillance. This report highlights the critical role of CBCT-histopathology integration in managing atypical FD and advocates for standardized follow-up protocols.

## Keywords
- Medicine
- Fibrous dysplasia
- Histopathology
- Radiography
- Radiology
- GNAS complex locus
- Asymptomatic
- Maxillary sinus
- Lesion
- Masticatory force
- Pathology
- Dysplasia
- Sinus (botany)
- Craniofacial
- Perioperative
- Maxilla
- Malignant transformation
- Osteitis fibrosa cystica
- Bone remodeling
- Oral cavity
- Xeroradiography
- Surgery

---
Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
Saat mengutip, gunakan DOI bila tersedia atau URL kanonis di atas.