Expression of mrNa forkhead box protein e3 (Foxe3) in congenital cataracts: a cross-sectional study

Abstract

BACKGROUND: The genetic causes of congenital cataracts vary widely and are related to mutations in specific genes. Forkhead box protein E3 (FoxE3) is a transcription factor required in the morphogenesis and differentiation of the anterior segment of the eye. This study aims to evaluate the FoxE3 gene mRNA expression in congenital cataract patients.METHODS: This was an analytic observational study with a cross-sectional design. The study sample comprised 14 congenital cataract patients and 12 non-cataract control samples. Blood samples were taken, and RT-PCR examined FoxE3 gene mRNA expression.RESULTS: The results showed a decrease in FoxE3 gene mRNA expression in 85.7% of case samples and increased expression in controls (91.7%). A relationship existed between the type of cataract and decreased FoxE3 gene mRNA expression in patients with congenital cataracts (P=0.000). A significant difference was found in the FoxE3 mRNA expression values between the congenital cataract and control groups (P=0.001).CONCLUSIONS: This study’s results indicate a decrease in FoxE3 gene mRNA expression in patients with congenital cataracts, along with a relationship between the type of cataract and decreased FoxE3 gene mRNA expression in patients with congenital cataracts, especially nuclear cataracts.

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