# Expression of CTLA-4 as a prognostic factor in nasopharyngeal carcinoma: A cross-sectional study
> Prabowo F.A.

URL kanonis: https://discover.unhas.ac.id/publications/expression-of-ctla-4-as-a-prognostic-factor-in-nasopharyngeal-carcinoma-a-cross
Jurnal / Konferensi: International Journal of Surgery Open
Tahun terbit: 2024
DOI: https://doi.org/10.1097/IO9.0000000000000144
ISSN: 24058572
Kuartil SJR: Q3
Citations: 0

## Authors
- Prabowo F.A.

## Abstract
Introduction: Nasopharyngeal carcinoma (NPC) poses a significant health burden in Indonesia, often diagnosed in advanced stages and associated with significant morbidity and mortality. Immunotherapy, particularly targeting the CTLA-4 protein receptor, has emerged as a key treatment approach to enhance immune recognition of tumor cells. Despite its role as an immune checkpoint in malignancies, the potential of CTLA-4 mRNA expression in prognosis remains poorly studied. This study aims to evaluate the role of CTLA-4 expression as a prognostic factor in NPC to evaluate the improvement in host immune response in patients following chemoradiotherapy. Material and Methods: This cross-sectional study included patients diagnosed with stage III-IV NPC, measuring CTLA-4 mRNA levels before and after chemoradiotherapy using quantitative PCR. Staging was carried out in the group that had received chemoradiotherapy. Chemotherapy comprised cisplatin administration (once weekly at 30–40 mg/m 2 ), followed by radiation therapy ([60]Co or 6–8 MV linear accelerator) for 20–36 sessions. Results: CTLA-4 mRNA expression positively correlated with NPC staging in patients both before and after chemoradiotherapy. Higher expression of CTLA-4 was associated with more advanced NPC staging, while lower expression of CTLA-4 was observed in patients having undergone chemoradiotherapy in NPC stages III and IV. Conclusion: CTLA-4 mRNA expression may serve as a prognostic marker for improvement in host immune response following chemoradiotherapy.

## Keywords
- Medicine
- Nasopharyngeal carcinoma
- Cross-sectional study
- Oncology
- Internal medicine
- Pathology
- Radiation therapy

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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