# Epitope-Based Immunoinformatics Approach on Nucleocapsid Protein of Severe Acute Respiratory Syndrome-Coronavirus-2
> Rakib A.

URL kanonis: https://discover.unhas.ac.id/publications/epitope-based-immunoinformatics-approach-on-nucleocapsid-protein-of-severe-acute
Jurnal / Konferensi: Molecules Basel Switzerland
Tahun terbit: 2020
DOI: https://doi.org/10.3390/molecules25215088
ISSN: 14203049
Kuartil SJR: Q1
Citations: 44

## Authors
- Rakib A.

## Abstract
With an increasing fatality rate, severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has emerged as a promising threat to human health worldwide. Recently, the World Health Organization (WHO) has announced the infectious disease caused by SARS-CoV-2, which is known as coronavirus disease-2019 (COVID-2019), as a global pandemic. Additionally, the positive cases are still following an upward trend worldwide and as a corollary, there is a need for a potential vaccine to impede the progression of the disease. Lately, it has been documented that the nucleocapsid (N) protein of SARS-CoV-2 is responsible for viral replication and interferes with host immune responses. We comparatively analyzed the sequences of N protein of SARS-CoV-2 for the identification of core attributes and analyzed the ancestry through phylogenetic analysis. Subsequently, we predicted the most immunogenic epitope for the T-cell and B-cell. Importantly, our investigation mainly focused on major histocompatibility complex (MHC) class I potential peptides and NTASWFTAL interacted with most human leukocyte antigen (HLA) that are encoded by MHC class I molecules. Further, molecular docking analysis unveiled that NTASWFTAL possessed a greater affinity towards HLA and also available in a greater range of the population. Our study provides a consolidated base for vaccine design and we hope that this computational analysis will pave the way for designing novel vaccine candidates.

## Keywords
- Coronavirus
- Epitope
- Human leukocyte antigen
- Virology
- Biology
- Major histocompatibility complex
- Pandemic
- Immunology
- Immune system
- Antigen
- Population
- Disease
- Infectious disease (medical specialty)
- Medicine
- Coronavirus disease 2019 (COVID-19)
- Environmental health
- Pathology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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