# elevated interleukin-6 serum levels in pregnant women with coronavirus disease 2019
> Syarifuddin D.R.

URL kanonis: https://discover.unhas.ac.id/publications/elevated-interleukin-6-serum-levels-in-pregnant-women-with-coronavirus-disease-2
Jurnal / Konferensi: Gazzetta Medica Italiana Archivio Per Le Scienze Mediche
Tahun terbit: 2024
DOI: https://doi.org/10.23736/S0393-3660.24.05444-5
ISSN: 03933660
Kuartil SJR: Q4
Citations: 0

## Authors
- Syarifuddin D.R.

## Abstract
BACKGROUND: The potential impact of coronavirus disease 2019 (COVID-19) on the health of expectant mothers and fetuses has strained attention. Pregnant women are considered a vulnerable category to respiratory infections. Moreover, several inflammatory cytokines are 2-100 times more abundant in COVID-19 with cytokine storm than in normal individuals; interleukin 6 (IL-6) exhibits much higher elevations. The aim of this study was to investigate potential relationships between IL-6 serum levels and severity of COVID-19 symptoms in pregnant women.METHODS: In this cross-sectional study, 62 pregnant women who met the eligibility criteria were divided into two groups: those who tested positive for COVID-19 (N.=31) and those who tested negative (N.=31). The participants were selected through consecutive sampling. The concentration of IL-6 in the blood sample was measured using ELISA methods.RESULTS: The COVID-19 positive group had a higher median IL-6 serum level (45.35 [35.15-153.99] vs. 38.86±11.43 [15.02-59.52], P=0.03) than the negative group. On the other hand, the IL-6 serum level had comparable value according to the COVID-19 symptoms severity (88.35±36.14 ng/mL vs. 51.09±25.48 ng/mL vs. 56.02±33.20 ng/mL in moderate symptoms, mild symptoms, and asymptomatic, respectively; P=0.152).CONCLUSIONS: Although the IL-6 serum levels are not related to COVID-19 symptoms severity, an elevated of this biomarker was found in pregnant women with affected diagnoses.

## Keywords
- Medicine
- Asymptomatic
- Coronavirus disease 2019 (COVID-19)
- Internal medicine
- Biomarker
- Pregnancy
- Cross-sectional study
- Severity of illness
- Gastroenterology
- Disease
- Cytokine storm
- Interleukin 6
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
- Cytokine
- Pathology
- Infectious disease (medical specialty)
- Biochemistry
- Genetics
- Biology
- Chemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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