Eleutherin palmifolia Bulb Extract (EPBE) Reduce Diarrhea Symtomps and Increases Histopathology of Duodenum of Male Mice (Mus musculus)

Abstract

Dayak onion (Eleutherine palmifolia) is a plant endemic to Kalimantan that is traditionally used by the Dayak people as herbal medicine.The content of tannin and flavonoids in Dayak onion has the potential for use as antidiarrheal therapy.This study aims to evaluate the effectiveness of Dayak onion extract on antidiarrheal activity and the improvement of duodenal histopathology in male mice (Mus musculus) induced by Oleum Richini.The antidiarrheal test was performed using a diarrhea protection model induced by Oleum Richini.The mice were divided into six groups: Non treatment group which was given distilled water without induction,a negative control group (KN(-)) which was given Na-CMC and induced with Oleum Richini, a positive control group (KP(+)) which was given loperamide suspension and induced with Oleum Richini, and three treatment groups which were given Dayak onion extract at doses of 250 mg/kg BW, 500 mg/kg BW, and 750 mg/kg BW, each induced with Oleum Richini.Diarrhea parameters, including defecation frequency and stool consistency, were statistically analyzed using ANOVA and Kruskal-Wallis tests.After treatment showed that the dose of 250 mg/kg BW was effective but not as effective as Loperamide, while the doses of 500 mg/kg BW and 750 mg/kg BW showed effectiveness equivalent to KP(+).Histopathological analysis showed that a dose of 500 mg/kg BW can improve inflammation in the duodenum of mice.Dayak onion extract at a dose of 500 mg/kg BW is effective as an antidiarrheal and is able to improve duodenal histopathology in male mice induced by Oleum Richini. RESULT:The results showed that the dose of 250 mg/kg BW was effective but not as effective as Loperamide, while the doses of 500 mg/kg BW and 750 mg/kg BW showed effectiveness equivalent to KP(+).Histopathological analysis showed that a dose of 500 mg/kg BW can improve inflammation in the duodenum of mice CONCLUSIONThe conclusion of this study is that Dayak onion extract at a dose of 500 mg/kg BW is effective as an antidiarrheal and is able to improve duodenal histopathology in male mice induced by Oleum Richini.

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