# Effects of Stromal Vascular Fraction and Platelet-Rich Plasma Treatment on Capillary Histopathology During Anal Trauma Healing in Rats: An in Vivo Study
> Darwin

URL kanonis: https://discover.unhas.ac.id/publications/effects-of-stromal-vascular-fraction-and-platelet-rich-plasma-treatment-on-capil
Jurnal / Konferensi: Iium Medical Journal Malaysia
Tahun terbit: 2023
DOI: https://doi.org/10.31436/IMJM.V22I2.2204
ISSN: 27352285
Kuartil SJR: Q4
Citations: 3

## Authors
- Darwin

## Abstract
INTRODUCTION: Anal traumas, such as blunt and penetrating injuries to the perineum, can disrupt the anal sphincter and cause considerable morbidity. Non-invasive anal trauma therapies have been widely developed, including growth factors administered as platelet-rich plasma (PRP) and stromal vascular fraction (SVFs) containing adipose[1]derived stem cells (ASCs) and limited growth factor. This study aimed to assess PRP and SVF effects on capillary histopathology in the anal trauma Wistar rat model. MATERIALS AND METHODS: This experimental study used a rat model. Rats were divided into three groups: Group A (n=12) was treated with PRP and SVFs; Group B (n=12) was treated with normal saline (placebo); Group C (n=4) was sacrificed on day 0 to obtain baseline capillary counts. Groups A and B were further divided into three subgroups, sacrificed on days 1, 7, and 14 post-treatment. RESULTS: Capillary counts significantly showed higher density between Groups A and B (p=0.037, analysis of variance). On day 7, there was a significant difference between Groups A and B (p=0.001). CONCLUSION: Mean capillary density significantly improved in anal trauma treated with a combination of PRP and SVFs compared to control. Our findings support the use of PRP and SVFs to aid recovery of patients with anal trauma.

## Keywords
- Medicine
- Platelet-rich plasma
- Histopathology
- Stromal vascular fraction
- Saline
- Stromal cell
- Platelet
- In vivo
- Surgery
- Pathology
- Urology
- Internal medicine
- Biology
- Biotechnology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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