Effects of Rosemary (Rosmarinus officinalis L.) leaf extract on angular cheilitis induced by staphylococcus aureus and Candida albicans in male Wistar rats

Abstract

Objective: The study aimed to determine the effect of rosemary (Rosmarinus officinalis L.) leaf extract on healing angular cheilitis induced byStaphylococcus aureus and Candida albicans in male Wistar rats.Methods: We assessed 24 male Wistar rats that were divided into four groups: The first group was induced by S. aureus and given rosemary leafextract, the second group was induced by S. aureus and given gentamicin, the third group was induced by C. albicans and given rosemary leaf extract,and the fourth group was induced by C. albicans and given miconazole. All rats in each group were treated, and wound length and erythema wereobserved for 7 days.Results: The average wound length on the 7th day was 0.00±0.0 mm in the first group, 0.29±0.4 mm in the second group, 0.00±0.0 mm in the thirdgroup, and 0.25±0.2 mm in the fourth group. Statistical analysis demonstrated significant differences in wound length for each treatment group.Conclusion: Rosemary leaf extract has a healing effect on angular cheilitis induced by S. aureus and C. albicans in male Wistar rats.

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