Effectiveness of CAPE in reducing vascular permeability after brain injury

Abstract

Vascular endothelial growth factor (VEGF) is a trophic factor that is expressed in the central nervous system after brain injury. It is expressed in the brain after traumatic brain injury and functions as a powerful activator of angiogenesis and vascularity. Furthermore, VEGF is mitogenic and a potential mediator of vascular permeability. Various biochemical mediators of vascular permeability have been studied, but there is no specific therapy aimed at modulating cerebrovascular permeability that has been used as a clinical standard. We examined the effects of vascular permeability through VEGF expression in blood vessels after head trauma to Sprague-Dawley rats. We measured levels of VEGF in groups of rats that were given Caffeic Acid Phenethyl Ester (CAPE) and those that were not. We examined the effects of CAPE in 2 groups of rats subjected to brains injury. VEGF levels in blood were measured 3 times: 24 h before trauma and on days 4 and 7. The parameters of the serum VEGF levels were examined with sandwich ELISA. We found a significant decrease in VEGF levels (p < 0.05) in the group that was given CAPE than in the group that was not on day 4 and day 7. The group that was given CAPE had lower VEGF levels in rat a model of brain injury. VEGF is an indicator of vascular permeability activity in the blood, and CAPE can decrease it.

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