# Effectiveness Of 1% Metformin Gel And Xenograft On Bone Regeneration In Post Extraction Socket Through Osteoblast And Osteoclast Dynamics
> Oktawati S.

URL kanonis: https://discover.unhas.ac.id/publications/effectiveness-of-1-metformin-gel-and-xenograft-on-bone-regeneration-in-post-extr
Jurnal / Konferensi: Malaysian Journal of Medicine and Health Sciences
Tahun terbit: 2025
DOI: https://doi.org/10.47836/mjmhs.21.s2.14
ISSN: 16758544
Kuartil SJR: Q4
Citations: 0

## Authors
- Oktawati S.

## Abstract
Introduction: Basic components in engineering tissue is cells, scaffolding and signaling molecules. Bone graft is a bone reconstruction treatment that is a proponent in tissue engineering. Metformin is a diabetic medication also can be used as a signaling molecule in tissue engineering, regenerative agent in bone and soft tissue. Bone tissue is dynamic, with a decrease in osteoclast cell numbers and an increase in osteoblast cell numbers. The goal of this research is to determine the effect that metformin, with 1% formulation in bone regeneration in post-extraction sockets, which is determined through osteoblastic and osteoclastic dynamic. Method: Twenty-seven Cavia Cobaya had their incisivus extracted, then divided into negative control group with no treatment given, positive control group treated with xenograft, and Treatment group treated with xenograft plus 1% metformin gel. On day 7,14 and 28 rats were sacrificed, and histologically examined. Result: A decrease in osteoclast cells followed by an increase in osteoblast cell following 1% metformin gel and xenograft application Conclusion: Application of 1% Metformin Gel followed by Xenograft placement provide a major decrease in osteoclast cells and an increase in osteoblast cells.

## Keywords
- Osteoblast
- Osteoclast
- Metformin
- Chemistry
- Regeneration (biology)
- Internal medicine
- Cell
- Bone tissue
- Endocrinology
- Regenerative medicine
- Repopulation
- Cell growth
- Pharmacology
- Mesenchymal stem cell
- Bone healing
- Medicine
- Cell biology
- Tissue engineering
- Signal transduction
- Bone remodeling
- Cellular differentiation
- Transplantation

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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