# Effect of Stromal Vascular Fraction and Platelet-Rich Plasma on Epithelialization in Anal Trauma Healing in Wistar Rats
> Abdu M.

URL kanonis: https://discover.unhas.ac.id/publications/effect-of-stromal-vascular-fraction-and-platelet-rich-plasma-on-epithelializatio
Jurnal / Konferensi: Iium Medical Journal Malaysia
Tahun terbit: 2026
DOI: https://doi.org/10.31436/imjm.v25i01.2725
ISSN: 27352285
Kuartil SJR: Q4
Citations: 0

## Authors
- Abdu M.

## Abstract
INTRODUCTION: Anal trauma should be treated immediately; early debridement should be performed to prevent infection and sepsis. The use of stromal vascular fraction (SVFs) and platelet-rich plasma (PRP) have now become an alternative surgical alternative. The aim of this study was to determine the effect of stromal vascular fraction (SVFs) and platelet-rich plasma (PRP) on morphological scores for epithelialization during induced anal trauma healing in Wistar rats. MATERIAL and METHODS: This experimental study assessed 32 male Wistar rats over a 2-month period. The rats were randomly allocated into four groups: Group A (negative control), Group B (anal trauma treated with PRP + SVF), Group C (anal trauma without PRP + SVF), and Group D (donor rats for PRP and SVF preparation; excluded from outcome analysis). RESULT: Although Group B (PRP+SVF) demonstrated higher epithelialization scores compared with Group C (control), the differences were not statistically significant on Day 1 (p=0.083), Day 7 (p=0.157), or Day 14 (p=0.317). However, a significant improvement in morphological scores was observed in the within-group comparison of the PRP+SVF treatment group between Day 1 and Day 14 (p=0.049). CONCLUSION: The combination of PRP and SVFs led to a significant improvement in morphological scores for epithelialization within the treatment group (PRP+SVF group) over 14 days. However, this combination therapy did not demonstrate a statistically significant acceleration of wound healing when compared to the untreated control group at the observed time points.

## Keywords
- Stromal vascular fraction
- Medicine
- Wound healing
- Stromal cell
- Surgery
- Platelet-rich plasma
- Group A
- Urology
- Rat model
- Pathology
- Debridement (dental)
- Group B
- Gastroenterology
- Necrosis
- Plasma cell
- Internal medicine
- Bone healing
- Inflammation
- Lesion
- Blood plasma
- Significant difference
- Ischemia

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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