Effect of propolis combination with cefadroxil in accelerating clinical improvement in benign chronic suppurative otitis media

Abstract

Chronic suppurative otitis media has a high prevalence and is a health problem in the community. The study aims to assess the effect of propolis combined with cefadroxil in accelerating clinical improvement in patients with benign type CSOM. This study used experimental clinical trials, carried out at the clinic of ENT-HN RSUP Dr. Wahidin Sudirohusodo and Unhas Hospital during the period of October-December 2018. A total of 15 samples were divided into 2 groups, namely: the treatment group (given propolis 2 x 200 mg therapy combined with cefadroxil 2 x 500 mg and the control group (cefadroxil 2 x 500 mg and methylprednisolone 2x4 mg) In this study, the initial and final examination of treatment was carried out, namely: physical examination of ENT, Pure Tone Audiometry (PTA), laboratory, and endoscopy. The data were presented in the form of tabulations and narratives. The results show that administration of propolis and cefadroxil show improved hearing through a decrease of 7.09% air conduction compared to the control group and a 13.06% decrease in bone conduction compared to the control group, while inflammatory improvement marked by a decrease in leucocyte levels was 3.68% compared to the control group, a decrease in neutrophil levels 3.8% compared to the control group, the decrease in eosinophil levels was 4.71% compared to the control group while the size of the perforation, type and degree of deafness do not occur between the treatment and control groups. From the results of this study it can be concluded that in patients with benign type CSOM for the treatment group given propolis therapy combined with cefadroxil better and faster clinical improvement (tympanic membrane mucosa is not hyperemic and secretions dry), namely: on the day 3 to 7 days compared to the control group given cefadroxil and methylprednisolone therapy clinical improvement occurred in the 7th to 11th day range.

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