# Durian Seed-Derived nata de durio: A Novel Potential Dietary Fiber for Intestinal Health and Constipation
> Yustisia I.

URL kanonis: https://discover.unhas.ac.id/publications/durian-seed-derived-nata-de-durio-a-novel-potential-dietary-fiber-for-intestinal
Jurnal / Konferensi: Tropical Journal of Natural Product Research
Tahun terbit: 2024
DOI: https://doi.org/10.26538/tjnpr/v8i4.24
ISSN: 26160684
Kuartil SJR: Q3
Citations: 2

## Authors
- Yustisia I.

## Abstract
This study explored the health benefits of nata, a bacterial cellulose and potential dietary fiber source derived from durian seeds fermented by Acetobacter xylinum, namelynata de durio (NDD). Twenty-five male BALB/C mice were divided into five groups. Three groups received varying doses of NDD: 0.02 g/g BW, 0.04 g/g BW, and 0.08 g/g BW, respectively. One group received 0.04 g/g BW of inulin as a positive control (PC), and one group received only water as a negative control (NC). All groups received standard rodent chow and waterad libitum. During the 5-week intervention, body weight, defecation frequency, fecal quantity, fecal weight, and fecal consistency were recorded daily. Post-experiment, the mice were euthanized, and their colons were harvested for histological examination. All groups, except the PC group, maintained a healthy weight. The NDD group, especially at a dose of 0.08 g/g BW, showed significantly higher defecation frequency, fecal quantity, and fecal weight than the NC and PC groups, with softer but non-diarrheal feces. The NDD 0.08 group exhibited the best colon histology with the lowest erosion and inflammation scores. This study suggests that NDD supplementation is non-toxic, beneficial for intestinal health, and potentially serves as an anti-constipation agent.

## Keywords
- Constipation
- Dietary fiber
- Pro re nata
- Food science
- Medicine
- Chemistry
- Gastroenterology
- Internal medicine
- Ranibizumab
- Chemotherapy
- Bevacizumab

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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