# Doxorubicin induced immune abnormalities and inflammatory responses via HMGB1, HIF1-α and VEGF pathway in progressive of cardiovascular damage
> Syukri A.

URL kanonis: https://discover.unhas.ac.id/publications/doxorubicin-induced-immune-abnormalities-and-inflammatory-responses-via-hmgb1-hi
Jurnal / Konferensi: Annals of Medicine and Surgery
Tahun terbit: 2022
DOI: https://doi.org/10.1016/j.amsu.2022.103501
ISSN: 20490801
Citations: 53

## Authors
- Syukri A.

## Abstract
HMGB1, HIF-1α and VEGF has a pivotal regulator in DOX-induce cardiomyocyte damage and predominantly acts through different pathways. The role of HMGB1 in DOX-induced myocardial damage suggests that HMGB1 is a mediator of DOX-induced damage. In addition, DOX can inhibit HIF-1α activity where DOX can decrease HIF-1α expression and HIF-1α is also responsible for upregulation of several angiogenic factors, including VEGF. VEGF plays an important role in angiogenesis and anti-angiogenesis both in vitro and in vivo and reduces the side effects of DOX markedly. In addition, the administration of anti-angiogenesis will show an inhibitory effect on angiogenesis mediated by the VEGF signaling pathway and triggered by DOX in cells.

## Keywords
- HMGB1
- Medicine
- Proinflammatory cytokine
- Angiogenesis
- Doxorubicin
- Rage (emotion)
- Vascular endothelial growth factor
- Cancer research
- Immune system
- Disease
- Pharmacology
- Bioinformatics
- Immunology
- Inflammation
- VEGF receptors
- Internal medicine
- Biology
- Chemotherapy
- Neuroscience

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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