Dissolution improvement of ketoprofen through polymer matrix composite povidone K-30/TiO2

Abstract

Ketoprofen is a nonsteroidal anti-inflammatory drug that has been classified into Class II as per the Biopharmaceutics Classification System. This substance has low solubility i.e. only 51 mg/L at 22℃. Therefore, a study of ketoprofen modification prepared in Polymer Matrix Composite (PMC) using Povidone K-30, coated with TiO2 as an effort to improve its dissolution profile, had been conducted. Composite particles were prepared through a dissolving method with a ratio of ketoprofen: Povidone K30 i.e. 1: 1 (F1), 1: 2 (F2), and 1: 4 (F3). They were evaluated and continued on the coating process using TiO2 30%, 40%, and 50%. Results of the study revealed that the PMC provides an absence of chemical intervention against ketoprofen. All the used combination ratios improved the dissolution profile by using phosphate buffer media pH 7.5 for 60 minutes. After coating, a release profile was obtained by running it on phosphate buffer media at pH 6.8 for 8 hours, this showing a sustained release profile.

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