# Differences of Hepatitis B Serological Tests in Cirrhosis and Hepatocellular Carcinoma Patients
> Adam R.A.D.

URL kanonis: https://discover.unhas.ac.id/publications/differences-of-hepatitis-b-serological-tests-in-cirrhosis-and-hepatocellular-car
Jurnal / Konferensi: Indonesian Journal of Clinical Pathology and Medical Laboratory
Tahun terbit: 2023
DOI: https://doi.org/10.24293/ijcpml.v30i1.2059
Kuartil SJR: Q4
Citations: 0

## Authors
- Adam R.A.D.

## Abstract
Cirrhosis and hepatocellular carcinoma (HCC) are the most common complications of chronic hepatitis B. Hepatitis B Virus (HBV) reactivation occurs in the inactive phase, characterized by reappearance of HBsAg or negative HBsAg. The prevalence of occult hepatitis B infection in cirrhosis and HCC ranges from 20% to 60%. This study aimed to analyze the differences in hepatitis B serological tests in patients with cirrhosis and HCC for diagnosis of acute or chronic hepatitis B. The current research was analytical and descriptive with a cross-sectional study design. This study involved 177 patients, including 50 cirrhosis patients and 127 HCC patients. Hepatitis B serological tests (HBsAg, HBeAg, anti-HBe, total anti-HBc) were analyzed using VIDAS instruments by the Enzyme-Linked Fluorescent Immunoassay (ELFA) method. Hepatitis B serological test results were grouped based on the interpretation of serological test results. The data were processed with the statistical test Kolmogorov-Smirnov test, independent T-test, and Chi-Square, and results with p<0.05 were reported as significant. This study found that most males suffer from cirrhosis and HCC due to chronic HBV infection, with a mean age of 57. Chronic hepatitis was most common in patients with cirrhosis and HCC (71.2%). There was no significant difference in the interpretation of the hepatitis B serological test between patients with cirrhosis and HCC, with a p-value of 0.230 (p > 0.05). There was no significant difference in interpreting the hepatitis B serological test between cirrhosis and HCC. Both reactive HBsAg and non-reactive HBsAg can be obtained in cirrhosis and HCC.

## Keywords
- Medicine
- Hepatocellular carcinoma
- Cirrhosis
- HBsAg
- Serology
- Gastroenterology
- Internal medicine
- Hepatitis B
- Hepatitis B virus
- HBeAg
- Hepatitis
- Immunology
- Virus
- Antibody

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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