# Development of Thermoresponsive-Gel-Matrix-Embedded Amoxicillin Trihydrate-Loaded Bovine Serum Albumin Nanoparticles for Local Intranasal Therapy
> Mardikasari S.A.

URL kanonis: https://discover.unhas.ac.id/publications/development-of-thermoresponsive-gel-matrix-embedded-amoxicillin-trihydrate-loade
Jurnal / Konferensi: Gels
Tahun terbit: 2022
DOI: https://doi.org/10.3390/gels8110750
ISSN: 23102861
Kuartil SJR: Q1
Citations: 17

## Authors
- Mardikasari S.A.

## Abstract
A high dose of amoxicillin is recommended as the first-line therapy for acute bacterial rhinosinusitis (ABR). However, oral administration of amoxicillin is connected to many adverse reactions coupled with moderate bioavailability (~60%). Therefore, this study aimed to develop a topical nasal preparation of amoxicillin, employing a thermoresponsive nanogel system to increase nasal residence time and prolong drug release. Rheological investigations revealed that formulations containing 21−23% w/w Poloxamer 407 (P407) were in accordance with the requirement of nasal administration (gelling temperature ~35 °C). The average hydrodynamic diameter (<200 nm), pH (6.7−6.9), and hypertonic osmolality (611−663 mOsmol/L) of the in situ gelling nasal nanogel appeared as suitable characteristics for local rhinosinusitis treatment. Moreover, taking into account the mucoadhesive strength and drug release studies, the 21% w/w P407 could be considered as an optimized concentration for effective nasal delivery. Antibacterial activity studies showed that the ability of amoxicillin-loaded in situ gelling nasal nanogel to inhibit bacterial growth (five common ABR pathogens) preserved its effectiveness in comparison to 1 mg/mL amoxicillin aqueous solution as a positive control. Altogether, the developed amoxicillin-loaded in situ gelling thermoresponsive nasal nanogel can be a potential candidate for local antibiotic therapy in the nasal cavity.

## Keywords
- Nasal administration
- Amoxicillin
- Bovine serum albumin
- Nanoparticle
- Matrix (chemical analysis)
- Materials science
- Chemistry
- Nanotechnology
- Chromatography
- Medicine
- Pharmacology
- Antibiotics
- Composite material
- Biochemistry

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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