# Development of Pluronic-Based Micelles from Palm Oil Bioactive Compounds Incorporated by a Dissolvable Microarray Patch to Enhance the Efficacy of Atopic Dermatitis Therapy
> Jannah K.H.

URL kanonis: https://discover.unhas.ac.id/publications/development-of-pluronic-based-micelles-from-palm-oil-bioactive-compounds-incorpo
Jurnal / Konferensi: Molecular Pharmaceutics
Tahun terbit: 2025
DOI: https://doi.org/10.1021/acs.molpharmaceut.4c00990
ISSN: 15438384
Kuartil SJR: Q1
Citations: 3

## Authors
- Jannah K.H.

## Abstract
The high content of vitamin E, including tocopherols and tocotrienols (TCF-TTE), in palm oil (<i>Elaeis guineensis</i>) has made it a promising candidate for the alternative treatment of atopic dermatitis (AD). However, the limited solubility of TCF-TTE has restricted its therapeutic efficacy. In this study, pluronic-based micelles (MCs) encapsulating palm oil-derived TCF-TTE were formulated with dissolvable microarray patch-micelles (DMP-MC) using carboxymethyl cellulose (CMC) synthesized from empty fruit bunches of palm to optimize its delivery for AD. The MC was prepared using a direct dissolution method using Pluronic F68 and F127. The results showed that MC increased the solubility of TCF-TTE, which was further confirmed by an <i>in vitro</i> study where 90.23 ± 2.07% TCF and 4.56 ± 1.36% TTE were released compared to the unencapsulated TCF-TTE extract. Furthermore, CMC biopolymers and MC integrated into DMP-MC with polyvinylpyrrolidone (PVP) exhibited favorable physical properties, such as mechanical strength and penetration ability. DMP-MC also exhibited a better platform with lower permeation, indicating higher retention and increased localized effects on AD skin than cream-MC. Additionally, dermatokinetic profile parameters showed significant improvement. The mean residence time (MRT) parameter indicated that TCF-TTE was retained for longer times 19.28 ± 0.02 h and 20.68 ± 0.01 h. Moreover, an <i>in vivo</i> study revealed that DMP-MC could relieve AD symptoms more rapidly than oral doses and cream-MC, indicating that DMP-MC proved to be more efficient. Furthermore, DMP-MC showed no tissue destruction (granulation and fibrosis) in rats treated with DMP-MC on the seventh day. Therefore, this study successfully developed the MC formula in DMP-MC formulation using synthesized CMC, which could potentially improve AD's therapeutic efficacy.

## Keywords
- Atopic dermatitis
- Poloxamer
- Palm oil
- Micelle
- Chemistry
- Chitosan
- Pharmacology
- Chromatography
- Medicine
- Food science
- Dermatology
- Organic chemistry
- Polymer
- Aqueous solution
- Copolymer

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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