# Development of PLGA micro- and nanorods with high capacity of surface ligand conjugation for enhanced targeted delivery
> Cao J.

URL kanonis: https://discover.unhas.ac.id/publications/development-of-plga-micro-and-nanorods-with-high-capacity-of-surface-ligand-conj
Jurnal / Konferensi: Asian Journal of Pharmaceutical Sciences
Tahun terbit: 2019
DOI: https://doi.org/10.1016/j.ajps.2018.08.008
ISSN: 18180876
Kuartil SJR: Q1
Citations: 62

## Authors
- Cao J.

## Abstract
Particle shape has been recognized as one of the key properties of nanoparticles in biomedical applications including targeted drug delivery. Targeting ability of shape-engineered particles depends largely on targeting ligands conjugated on the particle surface. However, poor capacity for surface ligand conjugation remains a problem in anisotropic nanoparticles made with biodegradable polymers such as PLGA. In this study, we prepared anisotropic PLGA nanoparticles with abundant conjugatable surface functional groups by a film stretching-based fabrication method with poly (ethylene-alt-maleic acid) (PEMA). Scanning electron microscopy images showed that microrods and nanorods were successfully fabricated by the PEMA-based film stretching method. The presence of surface carboxylic acid groups was confirmed by confocal microscopy and zeta potential measurements. Using the improved film-stretching method, the amount of protein conjugated to the surface of nanorods was increased three-fold. Transferrin-conjugated, nanorods fabricated by the improved method exhibited higher binding and internalization than unmodified counterparts. Therefore, the PEMA-based film-stretching system presented in this study would be a promising fabrication method for non-spherical biodegradable polymeric micro- and nanoparticles with high capacity of surface modifications for enhanced targeted delivery.

## Keywords
- Nanorod
- PLGA
- Materials science
- Zeta potential
- Nanotechnology
- Conjugated system
- Nanoparticle
- Drug delivery
- Chemical engineering
- Particle (ecology)
- Polymer
- Composite material
- Oceanography
- Engineering
- Geology

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Sumber: Discover Unhas — RIMS Universitas Hasanuddin.
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